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8.B.14.2.3
Matrix metalloproteinase-14, MMP14 or MT1-MMP, of 582 aas and 2 TMSs at the N- and C-termini. It mediates extracellular matrix (ECM) degradation following targetting and endocytosis into endolysosomes in a flotillin (TC# 8.A.21.3.1)-dependent process. MMP14 promotes cancerous growth and metastasis (Planchon et al. 2018).  

Accession Number:P50281
Protein Name:Matrix metalloproteinase-14
Length:582
Molecular Weight:65894.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Structure:
1BQQ   1BUV   2MQS   3C7X   3MA2   3X23   4P3C   4P3D   4QXU   5H0U   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS 
61:	LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ 
121:	HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF 
181:	FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE 
241:	LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT 
301:	SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM DGYPMPIGQF 
361:	WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP KHIKELGRGL PTDKIDAALF 
421:	WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG 
481:	NKYWKFNNQK LKVEPGYPKS ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA 
541:	AVVLPVLLLL LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV