Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.B.15.1.3
Precursor protein UG (U-actitoxin-Ugr1c; U-AITX-Ugr1c; AnmTX Ugr) of 162 aas and 1 N-terminal TMS.  Pi-AnmTX Ugr 9a-1: affects the ASIC3 channel (ACCN3) and produces analgesic effects. It produces a reversible inhibitory effect on both the transient and the sustained current of human ASIC3 channels expressed in X. laevis oocytes. It completely blocks the transient component (IC50=10 µM) and partially (48%) inhibits the amplitude of the sustained component (IC50=1.44 µM). Using in vivo tests in mice, it reverses inflammatory and acid-induced pain (Osmakov et al. 2013). The NMR structure is known (5LAH_A). 

Accession Number:R4ZCU1
Protein Name:Precursor protein UG
Length:162
Molecular Weight:17737.00
Species:Urticina grebelnyi (Painted anemone) [1264739]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

Structure:
2LZO     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MERILLCFIV ATLVAISMAN PRPISIDPPC WTCYYRDSSG NCAFDAIACG GARKRVPKPI 
61:	SIDPPCRTCY YRDSSGNCVY DAFGCGGARK RVPKPISIDP PCRTCYYRDS SGNCVYDAFG 
121:	CGGARKRVPK PISIDPPCRF CYHRDGSGNC VYDAYGCGAV RK