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8.B.16.1.1
Maurocalcine (maurocalcin; MCa) of the scorpion.  The 3-d structure is known (1C6W_A) (Mabrouk et al., 2007). This toxin stabilizes ryanodine receptor 1 (RyR1) opening in a long-lasting subconductance state (48%-60% of the full conductance state) (Fajloun et al. 2000, Xiao et al. 2016). Furthermore, it triggers calcium release from sarcoplasmic vesicles. Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals a subconductance that is abolished by PKA phosphorylation (Haji-Ghassemi et al. 2023).

Accession Number:P60254
Protein Name:Maurocalcin
Length:33
Molecular Weight:3865.00
Species:Scorpio maurus palmatus (Chactoid scorpion) [53957]
Location1 / Topology2 / Orientation3: Secreted1
Substrate calcium(2+)

Cross database links:

Pfam: PF08099   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019855 F:calcium channel inhibitor activity
GO:0009405 P:pathogenesis

References (2)

[1] “Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors.”  Fajloun Z.et.al.   10713267
[2] “A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel.”  Mosbah A.et.al.   10861934
Structure:
1C6W     

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FASTA formatted sequence 
1:	GDCLPHLKLC KENKDCCSKK CKRRGTNIEK RCR