8.B.24.3.1
Colicin M Immunity Protein of 141 aas and 1 TMSs. Cmi. This protein is able to protect a cell that harbors the plasmid ColBM-Cl139 encoding colicin M, against colicin M. Colicin M (Cma) is inactivated by interaction with Cmi. The structure of Cmi has been solved
at a resolution of 1.95Å. The monomeric structure
consists of a long N-terminal α-TMS and a four-stranded C-terminal
β-sheet. Dimerization is mediated by an extended interface
of hydrogen bond interactions between the α-helix and the four-stranded
β-sheet of the symmetry related molecule. Two intermolecular disulfide
bridges covalently connect this dimer to lock this complex (Usón et al. 2012).
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| Accession Number: | P18002 |
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| Protein Name: | Colicin-M immunity protein |
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| Length: | 141 |
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| Molecular Weight: | 16692.00 |
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| Species: | Escherichia coli [562] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MLTLYGYIRN VFLYRMNDRS CGDFMKVISM KFIFILTIIA LAAVFFWSED KGPACYQVSD
61: EQARTFVKND YLQRMKRWDN DVQLLGTEIP KITWEKIERS LTDVEDEKTL LVPFKAEGPD
121: GKRMYYGMYH CEEGYVEYAN D