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|---|---|
| Accession Number: | P56676 |
| Protein Name: | Huwentoxin-I aka HwTx-I |
| Length: | 81 |
| Molecular Weight: | 9319.00 |
| Species: | Ornithoctonus huwena (Chinese bird spider) (Selenocosmia huwena) [29017] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | |
Cross database links:
| Pfam: | PF07740 |
|---|---|
Gene Ontology
GO:0005576
C:extracellular region
GO:0045211
C:postsynaptic membrane
GO:0042734
C:presynaptic membrane
GO:0030550
F:acetylcholine receptor inhibitor activity
GO:0019855
F:calcium channel inhibitor activity
GO:0019870
F:potassium channel inhibitor activity
GO:0009405
P:pathogenesis
GO:0007268
P:synaptic transmission
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References (8)[1] “cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena.” Diao J.et.al. 14757201 [2] “Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena.” Liang S.-P.et.al. 8212049 [3] “Assignment of the three disulfide bridges of huwentoxin-I, a neurotoxin from the spider Selenocosmia huwena.” Zhang D.-Y.et.al. 8136023 [4] “Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena.” Zhou P.-A.et.al. 9028007 [5] “The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the Chinese bird spider Selenocosmia huwena.” Liang S.-P.et.al. 10736477 [6] “The effect of huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study.” Peng K.et.al. 11024489 [7] “Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution.” Qu Y.-X.et.al. 9263120 [8] “Chemical synthesis and characterization of R20A-HWTX-I, a mutant of huwentoxin-I with single residue replacement.” Wang X.-C.et.al. 11051826
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| Structure: | |
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MRASMFLALA GLVLLFVVCY ASESEEKEFP RELLFKFFAV DDFKGEERAC KGVFDACTPG 61: KNECCPNRVC SDKHKWCKWK L