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8.B.3.1.2
Hainantoxin-4 (processed)

Accession Number:P83471
Protein Name:Hainantoxin-4
Length:35
Molecular Weight:3995.00
Species:Selenocosmia hainana (Chinese bird spider) [209901]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

Pfam: PF07740   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042734 C:presynaptic membrane
GO:0019870 F:potassium channel inhibitor activity
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis
GO:0007268 P:synaptic transmission

References (6)

[1] “Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana.”  Liu Z.-H.et.al.   12827284
[2] “Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV.”  Xiao Y.et.al.   14512091
[3] “Inhibition of sodium channels in rat dorsal root ganglion neurons by Hainantoxin-IV, a novel spider toxin.”  Xiao Y.-C.et.al.   12518233
[4] “Synthesis and oxidative refolding of hainantoxin-IV.”  Liu Z.-H.et.al.   12098779
[5] “Solid-phase synthesis and biological characterization of S12A-HNTX-IV and R29A-HNTX-IV: two mutants of hainantoxin-IV.”  Xu X.et.al.   15859335
[6] “Structure-activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers.”  Li D.et.al.   15201273
Structure:
1NIY   1RYG   1RYV     

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FASTA formatted sequence 
1:	ECLGFGKGCN PSNDQCCKSS NLVCSRKHRW CKYEI