8.B.32.1.4
α-Conotoxin LvIA of 37 aas and 1 TMS. This toxin blocks alpha-3-beta-2/CHRNA3-CHRNB2 nAChR with high selectivity (IC50=8.7 nM (on rat) and 17.5 (on human)) (Luo et al. 2014). An alpha 4/7-Conotoxin LvIF from Conus lividus selectively blocks alpha3beta2 nicotinic acetylcholine receptor (Guo et al. 2021). The cryoEM structures are available (5XGL).
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| Accession Number: | L8BU87 |
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| Protein Name: | Alpha-conotoxin LvIA |
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| Length: | 37 |
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| Molecular Weight: | 3841.00 |
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| Species: | Conus lividus (Livid cone) [89426] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: FRGRDAAAKA SGLVGLTDRR GCCSHPACNV DHPEICG