8.B.4.1.9
Mu (μ)-conotoxin GVIIJ of 82 aas and 1 TMS.  Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin (GVIIJ (SSG)) blocks Nav1.1/SCN1A (Kd=11 nM), Nav1.2/SCN2A (Kd=11 nM), Nav1.3/SCN3A (Kd=15 nM), Nav1.4/SCN4A (Kd=4.7 nM), Nav1.6/SCN8A (Kd=360 nM) and Nav1.7/SCN9A (Kd=41 nM) (Gajewiak et al. 2014; Zhang et al. 2015). Coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) protects rNav1.1-1.7 against block by the toxin (Wilson et al. 2015).