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8.B.5.2.1
Protoxin-2 (ProTx2; ProTx-II)

Accession Number:P83476
Protein Name:Protoxin-2 aka ProTx2
Length:30
Molecular Weight:3833.00
Species:Thrixopelma pruriens (Green velvet) [213387]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

Gene Ontology

GO:0005576 C:extracellular region
GO:0019855 F:calcium channel inhibitor activity
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis

References (7)

[1] “Two tarantula peptides inhibit activation of multiple sodium channels.”  Middleton R.E.et.al.   12475222
[2] “Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains.”  Smith J.J.et.al.   15632158
[3] “Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.”  Smith J.J.et.al.   17339321
[4] “ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.”  Priest B.T.et.al.   17087985
[5] “Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.”  Sokolov S.et.al.   18156314
[6] “ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.”  Schmalhofer W.A.et.al.   18728100
[7] “Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.”  Edgerton G.B.et.al.   18657562
Structure:
2N9T   5O0U   5TCZ   6MK4   6N4I   6N4Q   6N4R     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	YCQKWMWTCD SERKCCEGMV CRLWCKKKLW