8.B.5.2.2
κ-Sparatoxin-Hv1b or heteropodatoxin 2 of 30 aas; It is an inhibitor
of voltage-gated potassium channels of the Kv4/KCND family (Ramracheya et al. 2010). Inhibition
of Kv4.3/KCND3 and Kv4.2/KCND2 is strongly voltage-dependent, while
inhibition of Kv4.1/KCND1 shows less voltage-dependence. Its binding
site may be near the potassium channel voltage sensor. This toxin also blocks
calcium channels.
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| Accession Number: | P58426 |
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| Protein Name: | Kappa-sparatoxin-Hv1b |
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| Length: | 30 |
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| Molecular Weight: | 3420.00 |
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| Species: | Heteropoda venatoria (Brown huntsman spider) [152925] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
|
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1: DDCGKLFSGC DTNADCCEGY VCRLWCKLDW