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| Accession Number: | P13494 |
| Protein Name: | Delta-hexatoxin-Hv1a |
| Length: | 42 |
| Molecular Weight: | 4856.00 |
| Species: | hadronyche versuta (Blue mountains funnel-web spider) [6904] |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | |
Cross database links:
| Pfam: | PF05353 |
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Gene Ontology
GO:0005576
C:extracellular region
GO:0019871
F:sodium channel inhibitor activity
GO:0009405
P:pathogenesis
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References (9)[1] “Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus.” Brown M.R.et.al. 3355530 [2] “Australian funnel-web spider toxin, versutoxin, enhances spontaneous synaptic activity in single brain neurons in vitro.” Chieng B.et.al. 8281423 [3] “Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.” Nicholson G.M.et.al. 7816562 [4] “Selective alteration of sodium channel gating by Australian funnel-web spider toxins.” Nicholson G.M.et.al. 9028001 [5] “Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels.” Little M.J.et.al. 9845331 [6] “Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.” Grolleau F.et.al. 11171353 [7] “Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin.” Gilles N.et.al. 11874465 [8] “Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin.” Wu Y.et.al. 18986214 [9] “The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel.” Fletcher J.I.et.al. 9384567
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| Structure: | |
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| FASTA formatted sequence |
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1: CAKKRNWCGK TEDCCCPMKC VYAWYNEQGS CQSTISALWK KC