9.A.14.10.3
Vasopressin (receptor 2, AVPR2, AVP2, AVPV2) of 371 aas and 7 TMSs. Pharmacochaperones post-translationally enhance cell surface expression of V2 by increasing the conformational stability of wild-type and mutant vasopressin V2 receptors (Wüller et al. 2004). New developments and concepts in the diagnosis and management of diabetes insipidus (AVP-deficiency and resistance) have been summarized and involve AVPR2 (Angelousi et al. 2023).
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| Accession Number: | P30518 |
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| Protein Name: | Vasopressin V2 receptor |
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| Length: | 371 |
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| Molecular Weight: | 40279.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA VALSNGLVLA
61: ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK ATDRFRGPDA LCRAVKYLQM
121: VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ
181: RNVEGGSGVT DCWACFAEPW GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP
241: SERPGGRRRG RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA
301: PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT
361: ASSSLAKDTS S