| |
|---|---|
| Accession Number: | P13473 |
| Protein Name: | LMP2 aka lamp2a aka LAMP2 |
| Length: | 410 |
| Molecular Weight: | 44961.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 2 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Single-pass type I membrane protein2 |
| Substrate | |
Cross database links:
| RefSeq: | NP_002285.1 NP_054701.1 |
|---|---|
| Entrez Gene ID: | 3920 |
| Pfam: | PF01299 |
| OMIM: |
300257 phenotype 309060 gene |
| KEGG: | hsa:3920 hsa:3920 |
Gene Ontology
GO:0010008
C:endosome membrane
GO:0016021
C:integral to membrane
GO:0005770
C:late endosome
GO:0005765
C:lysosomal membrane
GO:0005624
C:membrane fraction
GO:0005886
C:plasma membrane
GO:0031088
C:platelet dense granule membrane
GO:0031902
C:late endosome membrane
GO:0030168
P:platelet activation
GO:0002576
P:platelet degranulation
| |
References (57)[1] “Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.” Fukuda M.et.al. 3198605 [2] “The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.” Sawada R.et.al. 8517882 [3] “Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.” Fritz G.et.al. 8407947 [4] “Complete cDNA sequence of human lysosome-associated membrane protein-2.” Konecki D.S.et.al. 7999007 [5] “An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner.” Konecki D.S.et.al. 7488019 [6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [7] “The DNA sequence of the human X chromosome.” Ross M.T.et.al. 15772651 [8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [9] “Purification and characterization of human lysosomal membrane glycoproteins.” Mane S.M.et.al. 2912382 [10] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.” Zhang Z.et.al. 15340161 [11] “The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.” Carlsson S.R.et.al. 2243102 [12] “Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.” Carlsson S.R.et.al. 8323299 [13] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.” Zhang H.et.al. 12754519 [14] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.” Liu T.et.al. 16335952 [15] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [16] “Glycogen storage diseases presenting as hypertrophic cardiomyopathy.” Arad M.et.al. 15673802 [17] “Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene.” Musumeci O.et.al. 15907287 [18] “Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.” Fukuda M.et.al. 3198605 [19] “The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.” Sawada R.et.al. 8517882 [20] “Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.” Fritz G.et.al. 8407947 [21] “Complete cDNA sequence of human lysosome-associated membrane protein-2.” Konecki D.S.et.al. 7999007 [22] “An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner.” Konecki D.S.et.al. 7488019 [23] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [24] “The DNA sequence of the human X chromosome.” Ross M.T.et.al. 15772651 [25] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [26] “Purification and characterization of human lysosomal membrane glycoproteins.” Mane S.M.et.al. 2912382 [27] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.” Zhang Z.et.al. 15340161 [28] “The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.” Carlsson S.R.et.al. 2243102 [29] “Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.” Carlsson S.R.et.al. 8323299 [30] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.” Zhang H.et.al. 12754519 [31] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.” Liu T.et.al. 16335952 [32] “Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.” Eskelinen E.L.et.al. 16190986 [33] “Integral and associated lysosomal membrane proteins.” Schroeder B.et.al. 17897319 [34] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [35] “Initial characterization of the human central proteome.” Burkard T.R.et.al. 21269460 [36] “Glycogen storage diseases presenting as hypertrophic cardiomyopathy.” Arad M.et.al. 15673802 [37] “Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene.” Musumeci O.et.al. 15907287 [38] “Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.” Fukuda M.et.al. 3198605 [39] “The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.” Sawada R.et.al. 8517882 [40] “Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.” Fritz G.et.al. 8407947 [41] “Complete cDNA sequence of human lysosome-associated membrane protein-2.” Konecki D.S.et.al. 7999007 [42] “An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner.” Konecki D.S.et.al. 7488019 [43] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [44] “The DNA sequence of the human X chromosome.” Ross M.T.et.al. 15772651 [45] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [46] “Purification and characterization of human lysosomal membrane glycoproteins.” Mane S.M.et.al. 2912382 [47] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.” Zhang Z.et.al. 15340161 [48] “The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.” Carlsson S.R.et.al. 2243102 [49] “Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.” Carlsson S.R.et.al. 8323299 [50] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.” Zhang H.et.al. 12754519 [51] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.” Liu T.et.al. 16335952 [52] “Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.” Eskelinen E.L.et.al. 16190986 [53] “Integral and associated lysosomal membrane proteins.” Schroeder B.et.al. 17897319 | |
| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF TVRYETTNKT 61: YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA NFTKAASTYS IDSVSFSYNT 121: GDNTTFPDAE DKGILTVDEL LAIRIPLNDL FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG 181: TVSTNEFLCD KDKTSTVAPT IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ 241: LNITQDKVAS VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 301: ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL RVQPFNVTQG 361: KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL KHHHAGYEQF