9.B.198.2.4
Membrane-anchored lipid-binding protein, LAM6 or LTC1, of 693 aas and 1 (or more) TMSs (Wong and Levine 2016). It is involved in regulating various organellar membrane contact sites (Elbaz-Alon et al. 2015) and is involved in sterol transfer between intracellular membranes (Gatta et al. 2015). It selectively transports sterols between membranes in vivo and in vitro, and is involved in
stress-dependent formation of sterol-enriched vacuolar membrane domains
(Murley et al. 2015).
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| Accession Number: | Q08001 |
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| Protein Name: | Membrane-anchored lipid-binding protein LAM6 |
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| Length: | 693 |
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| Molecular Weight: | 78212.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass membrane protein2 |
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| Substrate |
sterol |
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1: MWGDSMRELG DAMDNELNAV KPVVEEGGMD GARKFIKGKS FQKSSTEHML ISPGRDGSVP
61: LNGLKSSPAD PHLSDVNSIL DNHRGGGETA LTSVNNIIMA TSTNGDSDGV DGDAKRPSIS
121: NCSSRSSFFD TVLSTFSLKS NSQDTVTNEV KNIEVQFASE EANKKFRQMF KPLAPNTRLI
181: TDYFCYFHRE FPYQGRIYLS NTHLCFNSTV LNWMAKLQIP LNEIKYLDKV TTNSSAISVE
241: TVTNRYTFSG FIARDEVFQL ITRVWSKENL TNINDVLEVD ERVSKKKGIS STPSSIFNNV
301: STNAYNDFIS TTTTEPTSRA SYMSENDMLI EEAIRSVDDY MGTPRASPSS SSSSSSSSSS
361: LGSSTTYYCR PVYRLKPNAP FQYEGPFHVQ ETMDFPYKPE ANNEYVLLER QFSVPPGLLF
421: IMMFNEDNPV FELSFLKTQD SSNISHIGTF EKVNKDGQHY REFQYTKQLH FPVGPKSTNC
481: EVAEILLHCD WERYINVLSI TRTPNVPSGT SFSTRTRYMF RWDDQGQGCI LKISFWVDWN
541: ASSWIKPMVE SNCKNGQISA TKDLVKLVEE FVEKYVELSK EKADTLKPLP SVTSFGSPRK
601: VAAPELTMVQ PESKPEAEAE ISEIGSDRWR FNWVNIIILV LLVLNLLYLM KLNKKMDKLT
661: NLMTHKDEVV AHATLLDIPA KVQWSRPRRG DVL