9.B.92.1.2
IZUMO1R, FolR4, JUNO of 250 aas. Receptor for IZUMO1 present at the cell
surface of oocytes (oolemma), which is essential for gamete recognition
and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary
adhesion event between sperm and egg that is required for fertilization
but is not sufficient for cell fusion. The ligand-receptor interaction
probably does not act as a membrane 'fusogen' (Sabetian et al. 2014). Does not bind folate.
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| Accession Number: | A6ND01 |
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| Protein Name: | Sperm-egg fusion protein Juno |
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| Length: | 250 |
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| Molecular Weight: | 28672.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Lipid-anchor2 |
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| Substrate |
|
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1: MACWWPLLLE LWTVMPTWAG DELLNICMNA KHHKRVPSPE DKLYEECIPW KDNACCTLTT
61: SWEAHLDVSP LYNFSLFHCG LLMPGCRKHF IQAICFYECS PNLGPWIQPV GSLGWEVAPS
121: GQGERVVNVP LCQEDCEEWW EDCRMSYTCK SNWRGGWDWS QGKNRCPKGA QCLPFSHYFP
181: TPADLCEKTW SNSFKASPER RNSGRCLQKW FEPAQGNPNV AVARLFASSA PSWELSYTIM
241: VCSLFLPFLS