| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.B.89.1.1 | The pore-forming protein, GjpA of 558 aas and up to 9 TMSs in a 1 (N-terminal) + 2 + 2 + 2 + 2 TMS arrangement with a fairly long (~ 120 aas) hydrophilic C-terminal domain. The channel has an average single-channel conductance of 800 pS in 1 M KCl, is moderately anion-selective, and does not show a voltage dependence for voltages between +100 and -100 mV. GjpA may import and export negatively charged molecules across the outer cell envelope (Jiménez-Galisteo et al. 2017). | Bacteria |
Actinomycetota | GjpA of Gordonia jacobaea |
|
1.B.89.1.2 | Uncharacterized protein with 476 aas and up to 8 predicted TMSs. | Bacteria |
Actinomycetota | UP of Mycolicibacterium smegmatis |
|
1.B.89.1.3 | PE family protein of 503 aas and up to 10 TMSs. The PE family is described under TC# 9.B.96 and is also called the PE-PGRS Family. | Bacteria |
Actinomycetota | PE family protein of Mycobacterium gordonae |
|
1.B.89.1.4 | Uncharacterized protein of 482 aas and up to 8 putative TMSs. | Bacteria |
Actinomycetota | UP of Gordonia polyisoprenivorans |
|
1.B.89.1.5 | Uncharacterized protein of 472 aas and ~ 6 putative TMSs. | Bacteria |
Actinomycetota | UP of Mycolicibacterium porcinum |
|
1.B.89.1.6 | Uncharacterized protein of 462 aas and ~ 8 putative TMSs | Bacteria |
Actinomycetota | UP of Mycobacterium aquaticum |
|
1.B.89.1.7 | Uncharacterized protein of 321 aas and ~ 8 TMSs. | Bacteria |
Actinomycetota | UP of Mycobacterium eburneum |
|
1.B.89.1.8 | Uncharacterized protein of 506 aas and ~ 8 putative TMSs. | Actinomycetota | UP of Mycolicibacterium aubagnense | |
|
1.B.89.1.9 | Uncharacterized protein of 766 aas and more than 8 potential TMSs. | Bacteria |
Actinomycetota | UP of Mycolicibacter senuensis |
|
1.B.89.1.10 | Uncharacterized protein of 524 aas and ~ 8 putative TMSs. TC BLAST with this protein brings up TC# 9.B.94.1.5 with a score of 0.0066 ( residues 198 - 318 aligning with residues 224 -351 in the protein with TC# 9.B.94.1.5. | Bacteria |
Actinomycetota | UP of Mycobacterium cookii |
|
1.B.89.1.11 | PE family protein of 556 aas and ~ 8 putative TMSs. In TC BLAST, this protein hits9.B.94.1.2 with an e-value of e-6 with filters, aligning residues 45 - 122 with residues 45 - 118 in 9.B.94.1.2. | Bacteria |
Actinomycetota | PE family protein of Mycobacterium ulcerans |
|
1.B.89.1.12 | PE family protein of 469 aas and ~ 8 putative TMSs. This protein brings up homologues of 1.B.89, 9.B.96 and 1.B.94 (the PE proteins of the latter systems). | Bacteria |
Actinomycetota | PE family protein of Mycobacterium gordonae |
|
1.B.89.1.13 | PE family protein of 1018 aas and ~ 8 putative TMSs. | Bacteria |
Actinomycetota | PE family protein of Mycobacterium canettii |
|
1.B.89.1.14 | PE family protein of 914 aas and up to ~12 TMSs. | Bacteria |
Actinomycetota | PE family protein of Mycobacterium tuberculosis |
|
1.B.89.1.15 | Uncharacterized protein of 486 aas and ~8 TMSs | Bacteria |
Actinomycetota | UP of Mycolicibacterium flavescens |
|
1.B.89.1.16 | Uncharacterized protein of 521 aas and ~ 8 TMSs. | Bacteria |
Actinomycetota | UP of Mycolicibacterium hodleri |
|
1.B.89.1.17 | Uncharacterized protein of 370 aas and ~ 8 TMSs | Bacteria |
Actinomycetota | UP of Mycolicibacterium porcinum |
|
1.B.89.1.18 | PE family protein of 325 aas and ~8 TMSs | Bacteria |
Actinomycetota | PE protein of Mycobacterium tuberculosis |
|
1.B.89.1.19 | Uncharacterized protein of 450 aas and ~8 TMSs. | Bacteria |
Actinomycetota | UP of Mycobacterium grossiae |
|
1.B.89.1.20 | Uncharacterized protein of 399 aas and ~ 10 TMSs. | Bacteria |
Actinomycetota | UP of Mycobacterium botniense |
|
1.B.89.1.21 | Putative porin protein encoded bya gene adjacent to one encoding a 6 TMS protein, YvaB, that may function in the export of a peptide toxin. The exporter has TC# 9.A.31.1.2. | Bacteria |
Actinomycetota | YvaB of Streptomyces coelicolor |
|
1.B.89.1.22 | The PE12 protein of 308 aas with possibly 3 - 5 α-helical TMSs. PE12 can suppress apoptosis and inhibit the proinflammatory cytokine response. PE12 is related to macrophage phagocytosis (Xu et al. 2024). | Bacteria |
Actinomycetota | PE12 of Mycobacterium tuberculosis |
|
1.B.89.1.23 | PE-PGRS family protein of 571 aas | Bacteria |
Actinomycetota | PE-PGRS protein of Mycobacteria liflandii |
|
1.B.89.1.24 | PE-PGRS family protein of 403 aa | Bacteria |
Actinomycetota | PE family protein of Mycobacterium liflandii |
|
1.B.89.2.1 | Uncharacterized protein of 279 aas and ~6 apparent TMSs asumming an α-helical structure. However, it might have a beta structure as an alternative. | Bacteria |
Actinomycetota | UP of Mycolicibacter heraklionensis |
|
1.B.89.2.2 | Uncharacterized protein of 21- aas and 2 TMSs. | Bacteria |
Actinomycetota | UP of Mycolicibacter arupensis |
|
1.B.89.2.3 | Uncharacterized protein of 233 aas and 4 or more TMSs | Bacteria |
Actinomycetota | UP of Mycobacterium shimoidei |
|
1.B.89.2.4 | PE-PPE domain-containing protein of 508 aas and ~8 TMSs. | Bacteria |
Actinomycetota | PE-PPE domain protein of Mycolicibacter icosiumassiliensis |