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View Proteins belonging to: The M-Zodatoxin-Lt8a Spider Toxin (ZST) Family

1.C.138.  The M-Zodatoxin-Lt8a Spider Toxin (ZST) Family 

It is an insecticidal, cytolytic and antimicrobial peptide (Vassilevski et al. 2008, Kuzmenkov et al. 2016).
It has insecticidal activity against the flesh fly, S. carnaria, and the cockroach, N. cinerea (Vassilevski et al. 2008). as well as D. melanogaster (Kuzmenkov et al. 2016). It has hemolytic activity against human erythrocytes (EC50=6 uM) (Vassilevski et al. 2008).  It has cytolytic activity against human leukocytes (EC50=3 uM) (Vassilevski et al. 2008).  It also has antibacterial activity against the Gram-positive bacteria A. globiformis VKM Ac-1112 (MIC=0.5 uM), and B. subtilis VKM B-501 (MIC=0.6-0.9 uM), and against the Gram-negative bacteria, E. coli and P. aeruginosa (Kuzmenkov et al. 2016). It forms voltage-dependent, ion-permeable channels in membranes, and at high concentrations, it causes cell membrane lysis (Vassilevski et al. 2008).

View Proteins belonging to: The M-Zodatoxin-Lt8a Spider Toxin (ZST) Family

References associated with 1.C.138 family:

Kozlov, S.A., A.A. Vassilevski, A.V. Feofanov, A.Y. Surovoy, D.V. Karpunin, and E.V. Grishin. (2006). Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. J. Biol. Chem. 281: 20983-20992. 16735513
Kuzmenkov, A.I., M.Y. Sachkova, S.I. Kovalchuk, E.V. Grishin, and A.A. Vassilevski. (2016). Lachesana tarabaevi, an expert in membrane-active toxins. Biochem. J. 473: 2495-2506. 27287558
Vassilevski, A.A., S.A. Kozlov, O.V. Samsonova, N.S. Egorova, D.V. Karpunin, K.A. Pluzhnikov, A.V. Feofanov, and E.V. Grishin. (2008). Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom. Biochem. J. 411: 687-696. 18215128