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2.A.1.14.18
Pantothenate:H+ symporter, Fen2

Accession Number:P25621
Protein Name:Pantothenate transporter FEN2
Length:512
Molecular Weight:58256.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron, pantothenate

Cross database links:

DIP: DIP-7672N
RefSeq: NP_009957.1   
Entrez Gene ID: 850394   
Pfam: PF07690   
KEGG: sce:YCR028C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015233 F:pantothenate transporter activity
GO:0006897 P:endocytosis
GO:0015887 P:pantothenate transmembrane transport

References (7)

[1] “Nucleotide sequence of 9.2 kb left of CRY1 on yeast chromosome III from strain AB972: evidence for a Ty insertion and functional analysis of open reading frame YCR28.”  Carbone M.L.A.et.al.   1332309
[2] “The complete DNA sequence of yeast chromosome III.”  Oliver S.G.et.al.   1574125
[3] “Yeast chromosome III: new gene functions.”  Koonin E.V.et.al.   8313894
[4] “FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast.”  Marcireau C.et.al.   8771708
[5] “The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter.”  Stolz J.et.al.   10373490
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MMKESKSITQ HEVERESVSS KRAIKKRLLL FKIDLFVLSF VCLQYWINYV DRVGFTNAYI 
61:	SGMKEDLKMV GNDLTVSNTV FMIGYIVGMV PNNLMLLCVP PRIWLSFCTF AWGLLTLGMY 
121:	KVTSFKHICA IRFFQALFES CTFSGTHFVL GSWYKEDELP IRSAIFTGSG LVGSMFSGFM 
181:	QTSIFTHLNG RNGLAGWRWL FIIDFCITLP IAIYGFIFFP GLPDQTSAVS KFSMTRYIFN 
241:	EQELHYARRR LPARDESTRL DWSTIPRVLK RWHWWMFSLV WVLGGENLGF ASNSTFALWL 
301:	QNQKYTLAQR NNYPSGIFAV GIVSTLCSAV YMSKIPRARH WHVSVFISLV MVIVAVLIRA 
361:	DPLNPKVVFS AQYLGGVAYA GQAVFFSWAN IICHADLQER AIVLASMNMF SGAVNAWWSI 
421:	LFFASDMVPK FERGCYALLA TAISSGIVSV VIRSLQIKEN LSKKQVPYID ANDMPGEDDD 
481:	DDNQDNENDG DDESMEVELH NEEMAEISNP FR