TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
2.A.109.1.1 | Tellurium resistance protein, TerC of 346 aas and 9 TMSs in a 5 + 4 TMS arrangement. Interactions with several other proteins including TerB have been demonstrated (Turkovicova et al. 2016). | Bacteria |
Pseudomonadota | TerC of E. coli (CAB42997) |
2.A.109.1.2 | Alx protein of 323 aas and 9 TMSs in a 2 + 3 + 4 TMS arrangement. | Bacteria |
Pseudomonadota | Alx of Neisseria meningitidis (F0N2E7) |
2.A.109.1.3 | YceF of 262 aas; possibly with 8 TMSs in a 2 + 2 + 2 + 2 TMS arrangement. | Bacteria |
Bacillota | YceF of Bacillus cereus (B5UIP4) |
2.A.109.1.4 | Putative transporter, YkoY (with 324 aas and 9 TMSs in a 1 + 2 + 2 + 4 TMS arrangement) (Kazanov et al. 2007; Meyer et al. 2011) | Bacteria |
Bacillota | YkoY of Bacillus subtilis (O34997) |
2.A.109.1.5 | TerC family efflux pump of 210 aas with 6 TMSs in a 3 + 3 TMS arrangement. | Bacteria |
Pseudomonadota | TerC family member of Sinorhizobium fredii |
2.A.109.1.6 | Uncharacterized protein of 352 aas with 8 TMSs in a 4 + 4 TMS arrangement. | Eukaryota |
Viridiplantae, Streptophyta | UP of Brachypodium distachyon (Purple false brome) (Trachynia distachya) |
2.A.109.1.7 | Membrane protein induced over 100x by alkaline conditions, Alx or YgjT of 321 aas and 9 TMSs (Stancik et al. 2002). This riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH. A set of acidic residues in the predicted TMSs of Alx play a role in Mn2+ export (Sharma and Mishanina 2023). | Bacteria |
Pseudomonadota | YgjT or Alx of E. coli |
2.A.109.2.1 | TerC homologue of 286 aas with 8 TMSs in a 2 + 1 + 1 + 2 + 2 TMS arrangement. | Bacteria |
Planctomycetota | TerC homologue of Rhodopirellula baltica |
2.A.109.2.2 | Hypothetical protein of 300 aas and 7 putative TMSs | Bacteria |
Planctomycetota | HP of Rhodopirellula baltica |
2.A.109.2.3 | 8 TMS membrane protein including a transmembrane domain homologous to other proteins in the TerC family (2.A.109) with the transmembrane domain having a 4 + 4 TMS arrangement, and a C-terminal domain (residues 622 - 889) with high sequence identity with hemolysin C and all members of the HlyC family (TC# 1.C.126), including some Mg2+ exporters in Cyclin M Mg2+ Exporter (CNNM) (TC family 1.A.112). The hydrophilic N-terminal CBS domain is an integrase domain but may bind ATP (Huang et al. 2021).
| Bacteria |
Pseudomonadota | Membrane protein of E. coli |
2.A.109.3.1 | DUF475; PRK14013 protein (341 aas; 9 or 10 TMSs in a 1 or 2 + 1 + 1 + 2 + 2 + 2 TMS arrangement). | Archaea |
Euryarchaeota | DUF475 protein of Methanocaldococcus vulcanius (C9RH03) |
2.A.109.3.2 | TerC homolog of 399 aas and 10 TMSs in a 2 + 1 + 1 + 2 + 2 + 2 TMS arrangement. | Bacteria |
Bacillati, Actinomycetota | TerC of Gordonia aichiensis |