TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.109.1.1









Tellurium resistance protein, TerC of 346 aas and 9 TMSs in a 5 + 4 TMS arrangement.  Interactions with several other proteins including TerB have been demonstrated (Turkovicova et al. 2016).

Bacteria
Pseudomonadota
TerC of E. coli (CAB42997)
2.A.109.1.2









Alx protein of 323 aas and 9 TMSs in a 2 + 3 + 4 TMS arrangement.

Bacteria
Pseudomonadota
Alx of Neisseria meningitidis (F0N2E7)
2.A.109.1.3









YceF of 262 aas; possibly with 8 TMSs in a 2 + 2 + 2 + 2 TMS arrangement.

Bacteria
Bacillota
YceF of Bacillus cereus (B5UIP4)
2.A.109.1.4









Putative transporter, YkoY (with 324 aas and 9 TMSs in a 1 + 2 + 2 + 4 TMS arrangement) (Kazanov et al. 2007Meyer et al. 2011)

Bacteria
Bacillota
YkoY of Bacillus subtilis (O34997)
2.A.109.1.5









TerC family efflux pump of 210 aas with 6 TMSs in a 3 + 3 TMS arrangement.

Bacteria
Pseudomonadota
TerC family member of Sinorhizobium fredii
2.A.109.1.6









Uncharacterized protein of 352 aas with 8 TMSs in a 4 + 4 TMS arrangement.

Eukaryota
Viridiplantae, Streptophyta
UP of Brachypodium distachyon (Purple false brome) (Trachynia distachya)
2.A.109.1.7









Membrane protein induced over 100x by alkaline conditions, Alx or YgjT of 321 aas and 9 TMSs (Stancik et al. 2002). This riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH. A set of acidic residues in the predicted TMSs of Alx play a role in Mn2+ export (Sharma and Mishanina 2023).

Bacteria
Pseudomonadota
YgjT or Alx of E. coli
2.A.109.2.1









TerC homologue of 286 aas with 8 TMSs in a 2 + 1 + 1 + 2 + 2 TMS arrangement.

Bacteria
Planctomycetota
TerC homologue of Rhodopirellula baltica
2.A.109.2.2









Hypothetical protein of 300 aas and 7 putative TMSs

Bacteria
Planctomycetota
HP of Rhodopirellula baltica
2.A.109.2.3









8 TMS membrane protein including a transmembrane domain homologous to other proteins in the TerC family (2.A.109) with the transmembrane domain having a 4 + 4 TMS arrangement, and a C-terminal domain (residues 622 - 889) with high sequence identity with hemolysin C and all members of the HlyC family (TC# 1.C.126), including some Mg2+ exporters in Cyclin M Mg2+ Exporter (CNNM) (TC family 1.A.112). The hydrophilic N-terminal CBS domain is an integrase domain but may bind ATP (Huang et al. 2021).

 

Bacteria
Pseudomonadota
Membrane protein of E. coli
2.A.109.3.1









DUF475; PRK14013 protein (341 aas; 9 or 10 TMSs in a 1 or 2 + 1 + 1 + 2 + 2 + 2 TMS arrangement).

Archaea
Euryarchaeota
DUF475 protein of Methanocaldococcus vulcanius (C9RH03)
2.A.109.3.2









TerC homolog of 399 aas and 10 TMSs in a 2 + 1 + 1 + 2 + 2 + 2 TMS arrangement.

Bacteria
Bacillati, Actinomycetota
TerC of Gordonia aichiensis