TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.109.1.1









Tellurium resistance protein, TerC.  Interactions with several other proteins including TerB have been demonstrated (Turkovicova et al. 2016).

Bacteria
Pseudomonadota
TerC of E. coli (CAB42997)
2.A.109.1.2









Alx protein (9-10 TMSs)

Bacteria
Pseudomonadota
Alx of Neisseria meningitidis (F0N2E7)
2.A.109.1.3









YceF (262 aas; 7 TMSs)

Bacteria
Bacillota
YceF of Bacillus cereus (B5UIP4)
2.A.109.1.4









Putative transporter, YkoY (8TMSs) (Kazanov et al. 2007Meyer et al. 2011)

Bacteria
Bacillota
YkoY of Bacillus subtilis (O34997)
2.A.109.1.5









TerC family efflux pump

Bacteria
Pseudomonadota
TerC family member of Sinorhizobium fredii
2.A.109.1.6









Uncharacterized protein of 352 aas

Eukaryota
Viridiplantae, Streptophyta
UP of Brachypodium distachyon (Purple false brome) (Trachynia distachya)
2.A.109.1.7









Membrane protein induced over 100x by alkaline conditions, Alx or YgjT of 321 aas and 9 TMSs (Stancik et al. 2002). This riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH. A set of acidic residues in the predicted TMSs of Alx play a role in Mn2+ export (Sharma and Mishanina 2023).

Bacteria
Pseudomonadota
YgjT or Alx of E. coli
2.A.109.2.1









TerC homologue

Bacteria
Planctomycetota
TerC homologue of Rhodopirellula baltica
2.A.109.2.2









Hypothetical protein of 300 aas and 7 putative TMSs

Bacteria
Planctomycetota
HP of Rhodopirellula baltica
2.A.109.2.3









8 TMS membrane protein including a transmembrane domain homologous to other proteins in the TerC family (2.A.109) with the transmembrane domain having a 4 + 4 TMS arrangement, and a C-terminal domain (residues 622 - 889) with high sequence identity with hemolysin C and all members of the HlyC family (TC# 1.C.126), including some Mg2+ exporters in Cyclin M Mg2+ Exporter (CNNM) (TC family 1.A.112). The hydrophilic N-terminal CBS domain is an integrase domain but may bind ATP (Huang et al. 2021).

 

Bacteria
Pseudomonadota
Membrane protein of E. coli
2.A.109.3.1









DUF475; PRK14013 protein (341 aas; 9 TMSs)

Archaea
Euryarchaeota
DUF475 protein of Methanocaldococcus vulcanius (C9RH03)