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2.A.22.3.3
The taurine:Na+ symporter, TauT or SLC6A6, (also transports β-alanine and γ-aminobutyric acid (GABA) (Tomi et al., 2008; Anderson et al., 2009). Regulation of the cellular content of taurine in mammalian cells has been reviewed (Lambert 2004). Biallelic mutation of the TauT-encoding gene is linked to early retinal degeneration (Preising et al. 2019). Oral taurine administration of retinal degeneration and cardiomyopathy reverses the phenotype (Ansar et al. 2019). Overexpression of SLC6A6 suppresses neointimal formation by inhibiting vascular smooth muscle cell proliferation and migration via Wnt/beta-catenin signaling (Rong et al. 2023).

Accession Number:P31641
Protein Name:NTTA aka SLC6A6
Length:620
Molecular Weight:69830.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), beta-alanine, gamma-aminobutyric acid, taurine

Cross database links:

RefSeq: NP_001127839.1    NP_003034.2   
Entrez Gene ID: 6533   
Pfam: PF00209   
OMIM: 186854  gene
KEGG: hsa:6533    hsa:6533   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005369 F:taurine:sodium symporter activity
GO:0006520 P:cellular amino acid metabolic process
GO:0006836 P:neurotransmitter transport
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006865 P:amino acid transport

References (8)

[1] “Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells.”  Jhiang S.M.et.al.   8382624
[2] “Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.”  Ramamoorthy S.et.al.   8010975
[3] “Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.”  Miyamoto Y.et.al.   8654117
[4] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[5] “Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells.”  Jhiang S.M.et.al.   8382624
[6] “Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.”  Ramamoorthy S.et.al.   8010975
[7] “Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.”  Miyamoto Y.et.al.   8654117
[8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF VLSVAGGFVG 
61:	LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII IGQYTSEGGI TCWEKICPLF 
121:	SGIGYASVVI VSLLNVYYIV ILAWATYYLF QSFQKELPWA HCNHSWNTPH CMEDTMRKNK 
181:	SVWITISSTN FTSPVIEFWE RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR 
241:	STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF 
301:	SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA 
361:	DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS 
421:	FLRKGYRREI FIAFVCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA 
481:	WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN 
541:	WAIGLGWSLA LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS 
601:	RTVMNGALVK PTHIIVETMM