TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.27.1.1









Glutamate:Na+ symporter, GltS, of 401 aas and 12 TMSs.  It transports L- and D-glutamate, α-methylglutamate and homocysteate. Swapping the order of the two halves (repeat units) does not decrease activity (Dobrowolski and Lolkema, 2010).

Bacteria
Pseudomonadota
GltS of E. coli (P0AER8)
2.A.27.1.2









Glutamate:Na+ symporter
Bacteria
Cyanobacteriota
GltS of Synechocystis PCC6803
2.A.27.1.3









Probable L-glutamate/N-acetylglutamate uptake porter, GltS.  Involved in N-acetylglutamate catabolism as a carbon and nitrogen source (Johnson et al. 2008).

Bacteria
Pseudomonadota
GltS of Pseudomonas aereuginosa
2.A.27.1.4









Sodium/glutamate symporter, GltS, YbfA, JemA, of 401 aas and 12 TMSs. Note, the Na+:Glutamate symporter with TC# 2.A.27.1.1 is also called GltS. YbfA regulates the sensitivity of E. coli K12 to plantaricin BM-1 via the BasS/BasR two- component regulatory system (Chen et al. 2021).

Bacteria
Pseudomonadota
GltS of E. coli
2.A.27.1.5









sodium:glutamate symporter of 476 aas and 12 TMSs, GltS. It has a Km for glutamate of 5 μM, but has low affinity for Na+. Glutamate uptake is inhibited by glu, gln, asp and asn (Boonburapong et al. 2012).

Bacteria
Cyanobacteriota
GltS
2.A.27.2.1









Glutamate:sodium symporter, GltS (Boonburapong et al. 2012).

Bacteria
Cyanobacteriota
GltS of Snyechococcus sp. ATCC27264 (Agmenellum guadruplicatum)
2.A.27.2.2









Archaeal GltS homologue

Archaea
Euryarchaeota
GltS of Methanosarcina mazei