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2.A.8.1.5 The D-serine transporter, DsdX (K_M=60µM) (may also transport D-threonine which inhibits D-serine uptake) (Anfora and Welch, 2006). Eliminating the dsdX gene renders the cell more sensitive to chloramphenicol (Duo et al. 2008).
Accession Number:	P08555
Protein Name:	DsdX permease
Length:	445
Molecular Weight:	47163.00
Species:	Escherichia coli (strain K12) [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	serine

DIP:	DIP-9481N
RefSeq:	AP_002965.1 NP_416866.1
Entrez Gene ID:	949103
Pfam:	PF02447
BioCyc:	EcoCyc:DSDX-MONOMER ECOL168927:B2365-MONOMER
KEGG:	ecj:JW2362 eco:b2365
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015128 F:gluconate transmembrane transporter activity GO:0015725 P:gluconate transport
References (9) [1] “Organization and transcriptional regulation of the Escherichia coli K-12 D-serine tolerance locus.” Noerregaard-Madsen M.et.al. 7592420 [2] “DNA sequence of the D-serine deaminase activator gene dsdC.” Palchaudhuri S.et.al. 3275618 [3] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.” Yamamoto Y.et.al. 9205837 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [6] “In vivo D-serine deaminase transcription start sites in wild-type Escherichia coli and in dsdA promoter mutants.” Bornstein-Forst S.M.et.al. 3029015 [7] “Analysis of the gluconate (gnt) operon of Bacillus subtilis.” Reizer A.et.al. 1659648 [8] “Adaptation of sucrose metabolism in the Escherichia coli wild-type strain EC3132.” Jahreis K.et.al. 12218016 [9] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MHSQIWVVST LLISIVLIVL TIVKFKFHPF LALLLASFFV GTMMGMGPLD MVNAIESGIG 
61:	GTLGFLAAVI GLGTILGKMM EVSGAAERIG LTLQRCRWLS VDVIMVLVGL ICGITLFVEV 
121:	GVVLLIPLAF SIAKKTNTSL LKLAIPLCTA LMAVHCVVPP HPAALYVANK LGADIGSVIV 
181:	YGLLVGLMAS LIGGPLFLKF LGQRLPFKPV PTEFADLKVR DEKTLPSLGA TLFTILLPIA 
241:	LMLVKTIAEL NMARESGLYI LVEFIGNPIT AMFIAVFVAY YVLGIRQHMS MGTMLTHTEN 
301:	GFGSIANILL IIGAGGAFNA ILKSSSLADT LAVILSNMHM HPILLAWLVA LILHAAVGSA 
361:	TVAMMGATAI VAPMLPLYPD ISPEIIAIAI GSGAIGCTIV TDSLFWLVKQ YCGATLNETF 
421:	KYYTTATFIA SVVALAGTFL LSFII

2.A.8.1.5
The D-serine transporter, DsdX (K_M=60µM) (may also transport D-threonine which inhibits D-serine uptake) (Anfora and Welch, 2006). Eliminating the dsdX gene renders the cell more sensitive to chloramphenicol (Duo et al. 2008).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

2.A.8.1.5The D-serine transporter, DsdX (KM=60µM) (may also transport D-threonine which inhibits D-serine uptake) (Anfora and Welch, 2006). Eliminating the dsdX gene renders the cell more sensitive to chloramphenicol (Duo et al. 2008).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

2.A.8.1.5
The D-serine transporter, DsdX (K_M=60µM) (may also transport D-threonine which inhibits D-serine uptake) (Anfora and Welch, 2006). Eliminating the dsdX gene renders the cell more sensitive to chloramphenicol (Duo et al. 2008).