TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.8.1.1









D-Gluconate:H+ symporter of 448 aas and 11 TMSs.  It is encoded in an operon with gluconate kinase (Fujita et al. 1986).

Bacteria
Bacillota
GntP of Bacillus subtilis
2.A.8.1.2









L-Idonate/D-Gluconate:H+ symporter, IdnT, GntW, YjgT, of 439 aas and 11 or 12 TMSs. Also called the GNT-II system (Bausch et al., 1998; Gómez et al. 2011).

Bacteria
Pseudomonadota
IdnT (GntW; YjgT) of E. coli
2.A.8.1.3









D-Fructuronate/D-gluconate:H+ symporter, GntP (Bates Utz et al., 2004)
Bacteria
Pseudomonadota
GntP of E. coli (P0AC94)
2.A.8.1.4









High affinity D-Gluconate:H+ symporter, GntT (GntM, UsgA, YhgC) of 438 aas and 11 or 12 TMSs (Porco et al., 1997). It is regulated at the transcriptional level by GntR and Crp (Peekhaus and Conway 1998).

Bacteria
Pseudomonadota
GntT of E. coli (P39835)
2.A.8.1.5









The D-serine transporter, DsdX (KM=60µM) (may also transport D-threonine which inhibits D-serine uptake) (Anfora and Welch, 2006). Eliminating the dsdX gene renders the cell more sensitive to chloramphenicol (Duo et al. 2008).

Bacteria
Pseudomonadota
DsdX of E. coli (P08555)
2.A.8.1.6









The putative D-glycerate transporter, GrtP. Regulated by glycerate-responsive regulator SdaR (Rodionov et al. 2011)

Bacteria
Pseudomonadota
GrtP of Shewanella oneidensis (Q8EG39)
2.A.8.1.7









Inner membrane uptake permease, YgbN, of 454 aas and 14 TMSs. Multi-ion irradiation caused the generation of a ygbN mutant (Song and Luo 2012).

Bacteria
Pseudomonadota
YgbN of Escherichia coli
2.A.8.1.8









Low-affinity (212 μM), gluconate-inducible, gluconate transporter (gluconate permease) (GntU/the Gnt-I system) (Tong et al. 1996). The gntU gene is in an operon with gntK, encoding a gluconate kinase (Tong et al. 1996).  This system has been utilized for the production of pyruvate from gluconate (Yang et al. 2017).

Bacteria
Pseudomonadota
GntU of Escherichia coli
2.A.8.1.9









Uncharacterized transporter HI_0092
Bacteria
Pseudomonadota
HI_0092 of Haemophilus influenzae
2.A.8.1.10









D-glycerate transporter of 430 aas and 14 putative TMSs.  The gene is next to and probably in the same operon with a gene encoding D-glycerate kinase.

Bacteria
Firmicutes
D-glycerate transporter of Enterococcus faecium
2.A.8.1.11









Putative gluconate analog transporter of 449 aas and 11 TMSs, YjhF.

Bacteria
Pseudomonadota
YjhF of E. coli
2.A.8.1.12









The putative histidine porter, YuiF. Regulated by Histidine repressor HisR (Ravcheev et al. 2011)

Bacteria
Bacillota
YuiF of Bacillus subtilis (O32105)
2.A.8.1.13









A putative propionate/butyrate/hydroxybutyrate transporter

Bacteria
Fusobacteriota
Putative propionate permease of Fusobacterium nucleatum (gi 19704150)
2.A.8.1.14









Putative D-beta-hydroxy butyrate permease, BhbP

Bacteria
Bacillota
BhbP of Bacillus cereus (Q81E21)
2.A.8.1.15









Gluconate porter of 463 aas and 13 TMSs, GntP (Letek et al. 2006; Porco et al. 2008).

Bacteria
Actinomycetota
GntP of Corynebacterium glutamicum (Brevibacterium saccharolyticum)