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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
2.A.86.1.1	Putative permease, PerM, of 353 aas and 7 or 8 TMSs.	Bacteria	Pseudomonadota	PerM of E. coli (P0AFI9)
2.A.86.1.2	Putative permease, YhhT (a member of the PurR purine regulon) with 7 TMSs in a 2 + 1 + 4 TMS arrangement.	Bacteria	Pseudomonadota	YhhT of E. coli (P0AGM0)
2.A.86.1.3	Putative permease, Yct2, encoded near the cta operon; of 385 aas and 7 or 8 TMSs in a 1 or 2 + 1 + 4 TMS arrangement.	Bacteria	Bacillota	Yct2 of Bacillus firmus (spQ04454)
2.A.86.1.4	Autoinducer-2 (AI-2; a furanosyl borate diester) exporter, TqsA (YdgG). It plays a role in biofilm formation (Nobre et al. 2009). Cryo-EM structures of two pentameric autoinducer-2 exporter from E. coli (TqsA (TC# 2.A.86.1.4) and YdiK (TC# 2.A.86.2.1) revealed the probable transport mechanism (Khera et al. 2022). Each of the 5 subunits is believed to be a functional unit, and an elevator-type mechanism has been suggested (Khera et al. 2022).	Bacteria	Pseudomonadota	TqsA of E. coli (POAFS5)
2.A.86.1.5	Permease (residues 1-380) fused to an ATP/GTP P-loop NTPase (AAA) superfamily domain (420-658) (Walker B motif; IstB-like)	Bacteria	Pseudomonadota	Fused permease-ATPase protein of Brucella abortus (C9VRY8)
2.A.86.1.6	Putative aldose-1-epimerase (N-terminus) fusion protein with a 7-8 TMS C-terminal transporter domain. It is a possible aldose transporter.	Bacteria	Actinomycetota	Aldose-1-epimerase-transporter fusion protein of Micrococcus luteus (D3LPG3)
2.A.86.1.7	Rv0205 (UFP0118) protein (376 aas, 8 putative TMSs) (may function with a heme uptake transporter) (TC# 2.A.6.5.5)	Bacteria	Actinomycetota	Rv0205 of Mycobacterium tuberculosis (O53656)
2.A.86.1.8	Putative transporter, YueF. Negatively regulates the sigW gene that encode the extra cytoplasmic sigma factor, sigma W, that activates genes which function in detoxification and the production of antimicrobial compounds (Turner and Helmann, 2000). SigW controls genes involved in transport and detoxification.	Bacteria	Bacillota	YueF of Bacillus subtilis (O32095)
2.A.86.1.9	Sporulation protein, YtvI of 371 aas and 6 - 8 TMSs. It is expressed under sigma E control, and null mutants are defective in spore formation (Eichenberger et al. 2003)). In Clostridium difficile, the orthologous ytvI gene is a virulence gene (Kociolek et al. 2018).	Bacteria	Bacillota	YtvI of Bacillus subtilis
2.A.86.1.10	Uncharacterized protein of 502 aas and 8 TMSs	Eukaryota	Rhodophyta	UP of Galdieria sulphuraria
2.A.86.1.11	7 TMS permease which is encoded by a gene adjacent to a spore germination receptor (2.A.3.9.5) and an ABC exporter (TC# 3.A.1.147.2).	Bacteria	Bacillota	Permease of Paenibacillus mucilaginosus
2.A.86.1.12	Putative permease of 322 aas and 6 TMSs, HalU (Besse et al. 2015).	Archaea	Euryarchaeota	HalU of Halobacterium sp. (strain AS7092)
2.A.86.1.13	Uncharacterized protein of 361 aas and 7 TMSs in a 2 + 5 TMS arrangement.	Eukaryota	Evosea	UP of Entamoeba histolytica
2.A.86.1.14	The sodium-lithium/proton antiporter; Na⁺ or Li⁺/H⁺ antiporter, UPF0118 or YtvI of 352 aas and 7 TMSs (Dong et al. 2017).	Bacteria	Bacillota	Na⁺ or Li⁺/H⁺ antiporter of Halobacillus andaensis
2.A.86.1.15	YtvI putative porter, of 363 aas and 8-10 TMSs in a 3 + 1, 2 or 3 + 3 + 1 arrangement. It is involved in virulence (Kociolek et al. 2018).	Bacteria	Bacillota	YtvI of Peptoclostridium difficile (Clostridium difficile)
2.A.86.1.16	Uncharacterized protein of 373 aas and 8 TMSs. Its gene is adjacent to an OmpA-like porin, so these two proteins may function together to export a substrate across both membranes in this diderm firmicute. The gene on the other side of the gene for this porter is an M4 peptidase, PepSY with a single N-terminal TMS, so it may be a periplasmic or outer membrane associated enzyme (Poppleton et al. 2017).	Bacteria	Bacillota	UP of Veillonella parvula
2.A.86.2.1	Purine regulon gene product, YdiK (under PurR control (Ravcheev et al., 2002)) YdiK is of 370 aas with 7 or 8 TMSs. Cryo-EM structures of two pentameric autoinducer-2 exporter from E. coli (TqsA (TC# 2.A.86.1.4) and YdiK (TC# 2.A.86.2.1)) revealed the probable transport mechanism (Khera et al. 2022). Each of the 5 subunits is believed to be a functional unit, and an elevator-type mechanism has been proposed (Khera et al. 2022)..	Bacteria	Pseudomonadota	YdiK of E. coli (B1LE48)
2.A.86.2.2	AI-2E homologue of 395 aas and 7 TMSs in a 2 + 1 + 3 + 1 TMS arrangement.	Bacteria	Myxococcota	AI-2E homologue of Myxococcus xanthus
2.A.86.2.3	Putative transporter	Archaea	Euryarchaeota	Putative transporter of Natronomonas pharaonis
2.A.86.3.1	Protein belonging to family UPF0118, NhaM, of 384 aas and 3 or 4 N-terrminal TMSs. Members of this family were functionally characterized as Na⁺, Li⁺, K⁺/H⁺ anitiporters by Shao et al. 2020, but the family was first identified by Dong et al. 2017. Shao et al. 2020 showed that a small region of 104 aas and 3 TMSs was sufficient for antiport activity following oligomerization. The N-terminal hydrophobic domain is the only one showing homology with other members of the family.	Bacteria	Planctomycetota	NhaM of Rhodopirellula maiorica
2.A.86.3.2	AI-2E transporter of 624 aas and ~8 TMSs in a 2 + 1 + 4 or 5 TMS arrangement, followed by a 220 residue C-terminal hydrophilic extension.	Bacteria	Acidobacteriota	Transporter of Pseudacidobacterium ailaaui (wood decay metagenome)
2.A.86.3.3	AI-2E family protein of 719 aas and 7 or 8 TMSs in a 2 or 3 + 1 + 4 TMS arrangement.	Bacteria	Pseudomonadota	AI-2E protein of Methyloligella halotolerans
2.A.86.4.1	TMEM245 protein of 879 aas and ~ 15 - 17 TMSs in a 1 or 2 + 4 + 2 + 1 + 1 or 2 + 4 TMS arrangement. Possibly there last 5 or 6 TMSs are homologous to and a repeat of the first 5 or 6 TMSs with 2 or 3 TMSs in the middle of the protein.	Eukaryota	Metazoa, Chordata	TMEM245 of Homo sapiens
2.A.86.4.2	Uncharacterized protein of 627 aas and possibly 12 TMSs in a 6 + 6 TMS arrangement.	Eukaryota	Viridiplantae, Streptophyta	UP of Arctium lappa (great burdock)
2.A.86.4.3	TMEM245 of 1189 aas and ~ 13 TMSs in an apparent 3 + 2 + 2 + 2 + 6 (2 + 4) TMS arrangement.	Eukaryota	Viridiplantae, Chlorophyta	TMEM245 of Micractinium conductrix
2.A.86.4.4	TMEM245 of 446 aas and 8 TMSs in an apparent 2 + 4 + 1 + 1 TMS arrangement.	Eukaryota	Metazoa, Mollusca	TMEM245 protein of Elysia marginata
2.A.86.4.5	Uncharacterized protein of 1096 aas and 12 or 13 TMSs in a 2 + 4 + 6 or 7 TMS arrangement.	Eukaryota	Apicomplexa	UP of Plasmodium falciparum