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2.B: Non-ribosomally Synthesized Porters

Non-ribosomally synthesized porters. These substances, like non-ribosomally synthesized channels, may be depsipeptides or non-peptide-like substances. They complex a cation in their hydrophilic interior and facilitate translocation of the complex across the membrane, exposing their hydrophobic exterior, by moving from one side of the bilayer to the other. If the free porter can cross the membrane in the uncomplexed form, the transport process can be electrophoretic, but if only the complex crosses the membrane, transport is electroneutral.