TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
8.A.1.1.1









Membrane Fusion Protein, EmrA, that function with MFS multidrug exporter, EmrB (Nishino and Yamaguchi 2001).

Bacteria
Pseudomonadota
EmrA of E. coli
8.A.1.1.2









The MFP cluster 1 protein, FarA (efflux of antimicrobial long chain fatty acids (Lee et al., 2006); functions with MFS carrier, FarB (TC# 2.A.1.3.20))
Bacteria
Pseudomonadota
FarA of Neisseria gonorrhoeae (Q9RQ30)
8.A.1.1.3









MdtN; acts with MdtO (TC# 2.A.85.6.1) and MdtP (TC# 1.B.17.3.9) (Sulavik et al., 2001).

Bacteria
Pseudomonadota
MdtN of E. coli (B1LPP9)
8.A.1.1.4









Membrane fusion protein, YiaV

Bacteria
Pseudomonadota
YiaV of E. coli
8.A.1.2.1









CzcB of MFP cluster 2 (functions with RND porter CzcA, TC# 1.A.6.1.2 and CzcC, TC# 1.B.17.2.1).

Bacteria
Pseudomonadota
CzcB of Alcaligenes eutrophus
8.A.1.2.2









Uncharacterized MFP of 314aas and 1 TMS.

Bacteria
Bdellovibrionota
MFP of Bdellovibrio exovorus
8.A.1.3.1









MFP cluster 3 (function with ABC porters) (Pimenta et al., 2005)
Bacteria
Pseudomonadota
HlyD of E. coli
8.A.1.3.2









MFP (cluster3). CyaD (functions with CyaB (TC# 3.A.1.109.2)) (Glaser et al., 1988)
Bacteria
Pseudomonadota
CyaD of Bordetella pertussis (P11091)
8.A.1.3.3









The MFP, EexE of cluster 3 (functions with the ABC porter EexD, (TC# 3.A.1.110.10) and OMF EexF (TC# 1.b.17.1.3)) (Gimmestad et al., 2006

).

Bacteria
Pseudomonadota
EexE of Azotobacter vinelandii (C1DS85)
8.A.1.3.4









Leukotoxin export MFP protein of 457 aas, TdcA (Guthmiller et al. 1995).  Functions with the ABC exporter, LtxB (TC# 3.A.109.8) and the TolC-like OMF protein, TdeA (TC# 1.B.17.3.11).

Bacteria
Pseudomonadota
Leukotoxin export MFP of Aggregatibacter (Actinobacillus; Haemophilus) actinomycetemcomitans
8.A.1.3.5









Uncharacterized MFP of 346 aas and 1 N-terminal TMS. Possibly functions with an RND pump.

Bacteria
Pseudomonadota
UP of Parvularcula oceani
8.A.1.3.6









Uncharacterized protein of 572 aas with two TMSs, one at residue 170 (the beginning of the MFP domain) and the last one at the C-terminus of the protein.  This first 160 aas are hydrophilic and are not homologous to most other MFPs. The gene encoding this protein (OUT43425) is adjacent to an ABC protein (OUT43424 of 719 aas)  that is homoloous to the entirety of the leukotoxin export protein, LtxB, of 707 aas with an M-C domain order (TC# 3.A.1.109.8), that functions with an MFP, LpxD (TC# 8.A.1.3.4), and a TolC-like protein for the export of the toxin from the cytoplasm to the external medium in one energy-coupled step.

Bacteria
Pseudomonadota
UP of Pelagibacteraceae bacterium TMED13 (marine metagenome)
8.A.1.4.1









Mesenterecin Y105 (bacteriocin) secresion accessory protein, MesE  of 457 aas (cluster 4). Functions with MesD; TC#3.A.1.112.8.

Bacteria
Bacillota
MesE of Leuconostoc mesenteroides
8.A.1.4.2









Competence factor transport accessory protein, ComB
Bacteria
Bacillota
ComB of Streptococcus pneumoniae
8.A.1.5.1









Open reading frame, Orf2
Bacteria
Bacillota
Orf2 of Lactobacillus gasseri
8.A.1.6.1









Acridine efflux pump constituent, AcrA
Bacteria
Pseudomonadota
AcrA of E. coli (P0AE06)
8.A.1.6.2









The multidrug efflux pump constituent, MdtA [may form a complex with MdtB and MdtC (2.A.6.2.12), both RND proteins. All three proteins appear to be required for resistance (Baranova and Nikaido, 2002).

Bacteria
Pseudomonadota
MdtA of E. coli (P76397)
8.A.1.6.3









Multidrug resistance protein MdtE (YhiU).  Functions with MdtF (TC# 8.A.1.6.3).

Bacteria
Pseudomonadota
MdtE of E. coli
8.A.1.6.4









Cation translocating membrane fusion protein of 295 aas

Bacteria
Planctomycetota
MFP of Rhodopirellula baltica
8.A.1.7.1









MFP, AaeA, that functions with AaeB, a γ-hydroxybenzoate efflux pump, a member of the Aromatic Acid Exporter Family (TC# 2.A.85) (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.

Bacteria
Pseudomonadota
AaeA of Escherichia coli (P46482)