8.A.256.  The Transcutaneous auricular Vagus Nerve Stimulation (TaVNS) Family 

TaVNS alleviates preeclampsia-induced vascular endothelial dysfunction via α7nAChR - IP3R1/GRP75/VDAC1 signal pathway.  Endothelial dysfunction is considered to play a pivotal role in the pathogenesis of preeclampsia (PE). TaVNS is a potential non-pharmaceutical alternative treatment for PE. Zhao et al. 2025 explored the mechanisms of taVNS on endothelial dysfunction.  taVNS may exert an anti-PE effect through ER-MITO interactions. These findings offer preliminary insights into PE pathogenesis, and suggest that the ACh/α7nAChR axis and IP3R1/GRP75/VDAC1 complex could be promising targets for future therapeutic investigation.