9.B.87.1.11
Crumbs, Crb of 2146 aas and 2 TMSs at the N- and C-termini. Plays
a central role in cell polarity establishment. Participates in the
assembly, positioning and maintenance of adherens junctions via its
interaction with the SAC complex. Controls the coalescence of the spots
of zonula adherens (ZA) into a adhesive ring around the cells (Tepass et al. 1990). Crb is an evolutionarily conserved transmembrane protein localised to the apical membrane of epithelial cells. Loss or mislocalisation of Crb is associated with disruption of apicobasal cell polarity. crb mRNA is apically enriched in epithelial cells, and, it accumulates in the oocyte of developing egg chambers (Bhagavatula and Knust 2021).
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| Accession Number: | P10040 |
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| Protein Name: | Protein crumbs |
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| Length: | 2146 |
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| Molecular Weight: | 233572.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Apical cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAKIANASLS QQQKQRQAET ATTTTTTVAA SVETATTTAR SRDRTKSAAQ ITSHLLKRAI
61: SVYSSPQWIP LFILIYLATD VASVAVPTKE AYFNGSTYLR LTTPMPIWDH SAISFRSCRG
121: GEILAQQYNK NSIVISVLND FLQISLAGPA VHGPNNRLDV KLPYQLLDNR WHTLQFKYEY
181: GNLYLHVDRA ASIFANSTYN SQFLTNQDIG YKDAILILGN SFSGCLLDGP GLQFVNNSTV
241: QNVVFGHCPL TPGPCSDHDL FTRLPDNFCL NDPCMGHGTC SSSPEGYECR CTARYSGKNC
301: QKDNGSPCAK NPCENGGSCL ENSRGDYQCF CDPNHSGQHC ETEVNIHPLC QTNPCLNNGA
361: CVVIGGSGAL TCECPKGYAG ARCEVDTDEC ASQPCQNNGS CIDRINGFSC DCSGTGYTGA
421: FCQTNVDECD KNPCLNGGRC FDTYGWYTCQ CLDGWGGEIC DRPMTCQTQQ CLNGGTCLDK
481: PIGFQCLCPP EYTGELCQIA PSCAQQCPID SECVGGKCVC KPGSSGYNCQ TSTGDGASAL
541: ALTPINCNAT NGKCLNGGTC SMNGTHCYCA VGYSGDRCEK AENCSPLNCQ EPMVCVQNQC
601: LCPENKVCNQ CATQPCQNGG ECVDLPNGDY ECKCTRGWTG RTCGNDVDEC TLHPKICGNG
661: ICKNEKGSYK CYCTPGFTGV HCDSDVDECL SFPCLNGATC HNKINAYECV CQPGYEGENC
721: EVDIDECGSN PCSNGSTCID RINNFTCNCI PGMTGRICDI DIDDCVGDPC LNGGQCIDQL
781: GGFRCDCSGT GYEGENCELN IDECLSNPCT NGAKCLDRVK DYFCDCHNGY KGKNCEQDIN
841: ECESNPCQYN GNCLERSNIT LYQMSRITDL PKVFSQPFSF ENASGYECVC VPGIIGKNCE
901: ININECDSNP CSKHGNCNDG IGTYTCECEP GFEGTHCEIN IDECDRYNPC QRGTCYDQID
961: DYDCDCDANY GGKNCSVLLK GCDQNPCLNG GACLPYLINE VTHLYNCTCE NGFQGDKCEK
1021: TTTLSMVATS LISVTTEREE GYDINLQFRT TLPNGVLAFG TTGEKNEPVS YILELINGRL
1081: NLHSSLLNKW EGVFIGSKLN DSNWHKVFVA INTSHLVLSA NDEQAIFPVG SYETANNSQP
1141: SFPRTYLGGT IPNLKSYLRH LTHQPSAFVG CMQDIMVNGK WIFPDEQDAN ISYTKLENVQ
1201: SGCPRTEQCK PNPCHSNGEC TDLWHTFACH CPRPFFGHTC QHNMTAATFG HENTTHSAVI
1261: VETTDVARRA IRSILDISMF IRTREPTGQV FYLGTDPRKA PTKNIGDSYV AAKLHGGELL
1321: VKMQFSGTPE AYTVGGQKLD NGYNHLIEVV RNQTLVQVKL NGTEYFRKTL STTGLLDAQV
1381: LYLGGPAPTR ESLLGATTEP GIIPVPGAGI PIEDTTVPKE ADDSRDYFKG IIQDVKVSNG
1441: SLNLIVEMYS LNVTDVQVNA KPLGAVTIDR ASVLPGEVSD DLCRKNPCLH NAECRNTWND
1501: YTCKCPNGYK GKNCQEIEFC QHVTCPGQSL CQNLDDGYEC VTNTTFTGQE RSPLAFFYFQ
1561: EQQSDDIVSE ASPKQTLKPV IDIAFRTRAG GTLLYIDNVD GFFEIGVNGG RVTITWKLSA
1621: LHFGESARFE KENTDGEWSR IYLRAHNSKL EGGWKGWESM VDPTPAFSTD IDQAAFQSLI
1681: ATSTQVYLGG MPESRQARGS TLSAQQGSQF KGCVGEARVG DLLLPYFSMA ELYSRTNVSV
1741: QQKAQFRLNA TRPEEGCILC FQSDCKNDGF CQSPSDEYAC TCQPGFEGDD CGTDIDECLN
1801: TECLNNGTCI NQVAAFFCQC QPGFEGQHCE QNIDECADQP CHNGGNCTDL IASYVCDCPE
1861: DYMGPQCDVL KQMTCENEPC RNGSTCQNGF NASTGNNFTC TCVPGFEGPL CDIPFCEITP
1921: CDNGGLCLTT GAVPMCKCSL GYTGRLCEQD INECESNPCQ NGGQCKDLVG RYECDCQGTG
1981: FEGIRCENDI DECNMEGDYC GGLGRCFNKP GSFQCICQKP YCGAYCNFTD PCNATDLCSN
2041: GGRCVESCGA KPDYYCECPE GFAGKNCTAP ITAKEDGPST TDIAIIVIPV VVVLLLIAGA
2101: LLGTFLVMAR NKRATRGTYS PSAQEYCNPR LEMDNVLKPP PEERLI