9.B.87.1.26 Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE1, of 322 aas and 1 TMS. It is a ligand-specific transporter trafficking between
intracellular organelles (TGN) and the plasma membrane. It plays a role in
autocrine regulation of cell growth, mediated by growth regulators
containing cell surface retention sequence binding (CRS) and may act as a
hyaluronan (HA) transporter, mediating either its uptake for catabolism
within lymphatic endothelial cells or its transport into the
lumen of afferent lymphatic vessels for subsequent re-uptake and
degradation in lymph nodes (Banerji et al. 1999). Ectodomain shedding of lymphatic vessel LYVE-1 is induced by vascular endothelial growth factor A (VEGF-A) (Nishida-Fukuda et al. 2016).
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Accession Number: | Q9Y5Y7 |
Protein Name: | Lymphatic vessel endothelial hyaluronic acid receptor 1 |
Length: | 322 |
Molecular Weight: | 35213.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
Substrate |
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1: MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ QLNFTEAKEA
61: CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI SPNPKCGKNG VGVLIWKVPV
121: SRQFAAYCYN SSDTWTNSCI PEIITTKDPI FNTQTATQTT EFIVSDSTYS VASPYSTIPA
181: PTTTPPAPAS TSIPRRKKLI CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL
241: LVLALLFFGA AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT
301: DKNPEESKSP SKTTVRCLEA EV