TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


9.B.87.1.26
Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE1, of 322 aas and 1 TMS. It is a ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. It plays a role in autocrine regulation of cell growth, mediated by growth regulators containing cell surface retention sequence binding (CRS) and may act as a hyaluronan (HA) transporter, mediating either its uptake for catabolism within lymphatic endothelial cells or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (Banerji et al. 1999). Ectodomain shedding of lymphatic vessel LYVE-1 is induced by vascular endothelial growth factor A (VEGF-A) (Nishida-Fukuda et al. 2016).  

Accession Number:Q9Y5Y7
Protein Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
Length:322
Molecular Weight:35213.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ QLNFTEAKEA 
61:	CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI SPNPKCGKNG VGVLIWKVPV 
121:	SRQFAAYCYN SSDTWTNSCI PEIITTKDPI FNTQTATQTT EFIVSDSTYS VASPYSTIPA 
181:	PTTTPPAPAS TSIPRRKKLI CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL 
241:	LVLALLFFGA AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT 
301:	DKNPEESKSP SKTTVRCLEA EV