9.B.87.1.42
Low density lipoprotein receotor, LDLR, of 860 aas and 2 TMSs, N- and C-terminal. It binds LDL, the major cholesterol-carrying lipoprotein of plasma, and
transports it into cells by endocytosis. In order to be internalized,
the receptor-ligand complexes must first cluster into clathrin-coated
pits (Davis et al. 1986). The LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus (Finkelshtein et al. 2013). LDLR deficiency promotes osteoclastogenesis by upregulating c-fos and NFATc1 expression, reducing cancellous bone mass in LDLR(-/-) mice (Qi et al. 2022).
anLDL receptor deficiency reduced bone mass in mice via the c-fos/NFATc1 pathway.
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| Accession Number: | P01130 |
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| Protein Name: | Low-density lipoprotein receptor |
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| Length: | 860 |
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| Molecular Weight: | 95376.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
61: ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
121: CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
181: PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
241: FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
301: DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
361: PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
421: SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
481: VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
541: KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
601: DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
661: PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
721: TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
781: EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
841: NQDGYSYPSR QMVSLEDDVA