9.B.87.1.46
Endosialin, also known as tumor endothelial marker1 or CD248, is a transmembrane glycoprotein of 757 aas and 2 TMSs, one at the N-terminus and one at the C-termini. CD248 is mainly expressed in cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC). Endosialin inhibits CD8+ T cell infiltration by inhibiting the expression and secretion of CXCL9/10 in CAFs, thus promoting HCC progression (Gan et al. 2024).
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| Accession Number: | Q91V98 |
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| Protein Name: | Endosialin |
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| Length: | 765 |
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| Molecular Weight: | 81813.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MLLRLLLAWV AAVPALGQVP WTPEPRAACG PSSCYALFPR RRTFLEAWRA CRELGGNLAT
61: PRTPEEAQRV DSLVGVGPAN GLLWIGLQRQ ARQCQPQRPL RGFIWTTGDQ DTAFTNWAQP
121: ATEGPCPAQR CAALEASGEH RWLEGSCTLA VDGYLCQFGF EGACPALPLE VGQAGPAVYT
181: TPFNLVSSEF EWLPFGSVAA VQCQAGRGAS LLCVKQPSGG VGWSQTGPLC PGTGCGPDNG
241: GCEHECVEEV DGAVSCRCSE GFRLAADGHS CEDPCAQAPC EQQCEPGGPQ GYSCHCRLGF
301: RPAEDDPHRC VDTDECQIAG VCQQMCVNYV GGFECYCSEG HELEADGISC SPAGAMGAQA
361: SQDLRDELLD DGEEGEDEEE PWEDFDGTWT EEQGILWLAP THPPDFGLPY RPNFPQDGEP
421: QRLHLEPTWP PPLSAPRGPY HSSVVSATRP MVISATRPTL PSAHKTSVIS ATRPPLSPVH
481: PPAMAPATPP AVFSEHQIPK IKANYPDLPF GHKPGITSAT HPARSPPYQP PIISTNYPQV
541: FPPHQAPMSP DTHTITYLPP VPPHLDPGDT TSKAHQHPLL PDAPGIRTQA PQLSVSALQP
601: PLPTNSRSSV HETPVPAANQ PPAFPSSPLP PQRPTNQTSS ISPTHSYSRA PLVPREGVPS
661: PKSVPQLPSV PSTAAPTALA ESGLAGQSQR DDRWLLVALL VPTCVFLVVL LALGIVYCTR
721: CGSHAPNKRI TDCYRWVTHA GNKSSTEPMP PRGSLTGVQT CRTSV