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1.B.6.2.1
Outer membrane porin precursor, OmpX (8 TM β-strands) (NMR structures in lipid bilayers solved (Mahalakshmi et al., 2007; Mahalakshmi and Marassi, 2008)).

Accession Number:P0A917
Protein Name:OmpX
Length:171
Molecular Weight:18603.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Genevestigator: P0A917
EchoBASE: EB2056
EcoGene: EG12135
eggNOG: COG3637
HEGENOM: HBG685626
DIP: DIP-48016N
RefSeq: AP_001445.1    NP_415335.1   
Entrez Gene ID: 944967   
Pfam: PF06316   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:EG12117-MONOMER    ECOL168927:B0814-MONOMER   
KEGG: ecj:JW0799    eco:b0814   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (7)

[1] “Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica.”  Mecsas J.et.al.   7836315
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB.”  Lomovskaya O.L.et.al.   8021175
[6] “Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.”  Molloy M.P.et.al.   9629924
[7] “The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence.”  Vogt J.et.al.   10545325
Structure:
1ORM   1Q9F   1Q9G   1QJ8   1QJ9   2M06   2M07   2MNH     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKKIACLSAL AAVLAFTAGT SVAATSTVTG GYAQSDAQGQ MNKMGGFNLK YRYEEDNSPL 
61:	GVIGSFTYTE KSRTASSGDY NKNQYYGITA GPAYRINDWA SIYGVVGVGY GKFQTTEYPT 
121:	YKHDTSDYGF SYGAGLQFNP MENVALDFSY EQSRIRSVDV GTWIAGVGYR F