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8.A.69 The Pro-apoptotic Bcl-2-Family Protein Bim (Bim) Family 

The pro-apoptotic Bcl-2-family protein Bim belongs to the BH3-only proteins known as initiators of apoptosis. Bim is constitutively inserted in the outer mitochondrial membrane via a C-terminal transmembrane anchor from where it can activate the effector of cytochrome c-release, Bax (Frank et al. 2015). Interactions of Bim with Tom70, Tom20 and more weakly with Tom40, all components of the Translocase of the Outer Membrane (TOM; TC# 3.A.8) have been documented. Protein receptors may be involved in the import process.  In isolated yeast mitochondria, lack of Tom70 or the TOM-components Tom20 or Tom22 did not affect the import of Bim into the outer mitochondrial membrane. In yeast, expression of Bim can sensitize the cells to Bax-dependent killing, but the physiological role of the Bim-TOM-interaction remains unclear.

This family belongs to the: Bcl-2 Superfamily.

References associated with 8.A.69 family:

Frank, D.O., J. Dengjel, F. Wilfling, V. Kozjak-Pavlovic, G. H├Ącker, and A. Weber. (2015). The pro-apoptotic BH3-only protein Bim interacts with components of the translocase of the outer mitochondrial membrane (TOM). PLoS One 10: e0123341. 25875815
Fukazawa, H., K. Noguchi, A. Masumi, Y. Murakami, and Y. Uehara. (2004). BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. Mol Cancer Ther 3: 1281-1288. 15486195
Marani, M., T. Tenev, D. Hancock, J. Downward, and N.R. Lemoine. (2002). Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol. Cell Biol. 22: 3577-3589. 11997495
O'Connor, L., A. Strasser, L.A. O'Reilly, G. Hausmann, J.M. Adams, S. Cory, and D.C. Huang. (1998). Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO. J. 17: 384-395. 9430630